Further FDA clinical trial holds may signal the end for checkpoint inhibitors in myeloma

With the placement of two more checkpoint inhibitor combination trials on partial hold, the US Food and Drug Administration (FDA) has now halted all such trials from four different pharmaceutical companies: Merck, Bristol-Myers Squibb, Celgene, and now Roche.  Roche and its subsidiary Genentech announced that the agency has placed a partial hold on two trials that combine atezolizumab (Tecentriq®) with lenalidomide (Revlimid®) or pomalidomide (Pomalyst®) to treat relapsed/refractory multiple myeloma.

University of California girds to combat cancer, a closer look at CAR-T cell therapy, and medical tourism to China—a wave of the future?

With new drug approvals and expanded indications for new myeloma drugs at an all-time high, there is a sense of optimism in the myeloma community. Yet, even as patients experience longer survival, myeloma remains very sneaky. The disease can evolve into resistant relapse phases, demanding new therapy.

Closing or Halting of Myeloma Immune Therapy Trials: A Major Setback for Patients and Drug Companies

When the US Food and Drug Administration (FDA) halted three Keytruda (pembrolizumab) clinical trials recently because of unexpected deaths, it was cause for concern. This week, the FDA has acted to close further studies involving the whole range of PD-1/ PD-L1 inhibitors combined with the IMiDs Revlimid (lenalidomide) and Pomalyst (pomalidomide) in order to forestall any further unexpected toxicities and/or deaths.

Daratumumab in the News Again: Showing Benefit in Frontline and at Relapse

On August 24th, Genmab announced that the ALCYONE trial, which compared the combination of daratumumab (Darzalex®) with VMP (Velcade®/melphalan/prednisone) to VMP alone, hit the primary endpoint for treatment of myeloma as a frontline therapy. The progression-free survival (PFS) for the VMP alone was 18.1 months versus “not reached” with the addition of daratumumab. Showing the added value of daratumumab is very important in Europe, where VMP is a standard frontline regimen.

With the Solar Eclipse, Millions Understand That Science is Not Fake News

At 10:21 a.m. Los Angeles time on Monday, August 21st, the moon covered 62% of the sun. In Oregon and across the US, there were 2.3 minutes of total darkness. Scientists had been informing everyone about this upcoming event for many years, and it occurred exactly on schedule: a natural event.

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