The 2019 American Society of Hematology (ASCO) Annual Meeting in Chicago is fast approaching (May 31-June 4). Out of a total of 4,950 abstracts released Wednesday, May 15, 210 are myeloma related. As usual, there is one oral session on Sunday, June 1 from 9:45 am -12:45 pm, which includes the top eight oral abstracts (numbers 8000 through 8007). I will review these, plus a couple of poster presentations that are worthy of mention (#8015 and #8023) to give my initial Top 10 Abstracts for ASCO 2019.