Daratumumab shows great promise in published report today

Submitted by blackswan on Fri, 08/28/2015 - 02:00

The major article today in the New England Journal of Medicine is a report  of a study with lead author, Dr. Henk Lokhorst (from VU University Medical center in Amsterdam, Netherlands) which summarizes the phase I – II trials results in 72 patients treated with daratumumab, anti-CD38 therapy.

New drug data challenge the ways we treat myeloma

Submitted by Dr. Brian GM Durie on Fri, 06/19/2015 - 03:13

At the recent annual meetings of the American Society of Clinical Oncology (ASCO) and the European Hematology Association (EHA), important data were presented on the monoclonal antibodies elotuzumab and daratumumab. The first acts against SLAMF7 and the second against CD38. These new targets on the surface of myeloma cells provide ways to attack myeloma separate from traditional chemotherapy and the immunomodulatory drugs (IMiDs) or proteasome inhibitor “novel” agents.